Metronidazole and Alcohol - how much can you have?
So antibiotics eey? The long standing tradition of not drinking while on antibiotics has come a reality this week.
In my quest to resume tradition of another booze fuelled weekend, I did a little research on this, as I originally thought that alcohol would inhibit the antibiotics, rendering them useless and therefore the course of medication is irrelevant. And the infection comes back and eats not only your healthy cells, but also your cat, TV, laptop AND drinking suit.
It appears that drinking does indeed change the effectivity of antibiotics, but not to such an extent where they stop working - the main worry is nausea, extreme vomiting and other fun effects - but it really does depends on what antibiotics you are on.
The first, err what's it called - Amoxicillin, is a penicillin based antibiotic - and is not really affected by the intake of alcohol. Drinking just after taking it isn't advised, but this is only because it can adversely affect the absorption into the stomach and digestive system - as with anything. So no actual reaction between the two.
Metronidazole however is a different kettle of fish. This can cause nausea, massive vomiting and tachycardia. So I wonder why?
It's something to do with limiting the body's ability to break down and metabolise the alcohol - by blocking the breakdown of propylene glycol in the liver. This increases the amount of propylene glycol in the blood, and can harm the liver and other fun items in the body that allow life to happen.
So it makes propylene glycol stay in my body for ages, so what does this do? Well it looks like it's used in loads of household goods, from deoderant sticks to being a moisturiser in cosmetics. It's even a safe food additive in the US (not checked other countries..) - However this method of ingestion (oral) is minimally effective, and is therefore deemed quite safe - but when propylene glycol is allowed into the bloodstream, intravenously as it were, it becomes quite dangerous.
To make use of this and try to find out how much booze I can actually consume before the propylene glycol becomes fatally toxic, I need to find out the fatal dose... for which there is no data.
Absorption rates in rats after ingestion is 90-100%, usually not building up in the body. But when breakdown is inhibited this could build up quickly.
Ingestion of a sufficient quantity can definitely cause death. 1g per KG of body weight, so say 90g of this stuff can affect the central nervous system, causing numbness, visual distortions etc.... Increase this to 3g/kg, and you get massively drunk, slurred speech and stupor/agitation mental state shifts.
Over that, you get coma, loss of reflexes and probably death.
So it's quite inconclusive unless data on how much of this stuff is held back by the body.
All of the above sounds like getting pissed anyway, but I don't think I will booze on during the course of these antibiotics. I will find out tomorrow.
In my quest to resume tradition of another booze fuelled weekend, I did a little research on this, as I originally thought that alcohol would inhibit the antibiotics, rendering them useless and therefore the course of medication is irrelevant. And the infection comes back and eats not only your healthy cells, but also your cat, TV, laptop AND drinking suit.
It appears that drinking does indeed change the effectivity of antibiotics, but not to such an extent where they stop working - the main worry is nausea, extreme vomiting and other fun effects - but it really does depends on what antibiotics you are on.
The first, err what's it called - Amoxicillin, is a penicillin based antibiotic - and is not really affected by the intake of alcohol. Drinking just after taking it isn't advised, but this is only because it can adversely affect the absorption into the stomach and digestive system - as with anything. So no actual reaction between the two.
Metronidazole however is a different kettle of fish. This can cause nausea, massive vomiting and tachycardia. So I wonder why?
It's something to do with limiting the body's ability to break down and metabolise the alcohol - by blocking the breakdown of propylene glycol in the liver. This increases the amount of propylene glycol in the blood, and can harm the liver and other fun items in the body that allow life to happen.
So it makes propylene glycol stay in my body for ages, so what does this do? Well it looks like it's used in loads of household goods, from deoderant sticks to being a moisturiser in cosmetics. It's even a safe food additive in the US (not checked other countries..) - However this method of ingestion (oral) is minimally effective, and is therefore deemed quite safe - but when propylene glycol is allowed into the bloodstream, intravenously as it were, it becomes quite dangerous.
To make use of this and try to find out how much booze I can actually consume before the propylene glycol becomes fatally toxic, I need to find out the fatal dose... for which there is no data.
Absorption rates in rats after ingestion is 90-100%, usually not building up in the body. But when breakdown is inhibited this could build up quickly.
Ingestion of a sufficient quantity can definitely cause death. 1g per KG of body weight, so say 90g of this stuff can affect the central nervous system, causing numbness, visual distortions etc.... Increase this to 3g/kg, and you get massively drunk, slurred speech and stupor/agitation mental state shifts.
Over that, you get coma, loss of reflexes and probably death.
So it's quite inconclusive unless data on how much of this stuff is held back by the body.
All of the above sounds like getting pissed anyway, but I don't think I will booze on during the course of these antibiotics. I will find out tomorrow.
Comments
I have drank 1 double shot of fireball and I am fine. Update after the 2nd, maybe 3rd>_<
I debated on day 3 whether or not to drink and decoded F it. I'm giving it a go. I took last pill at 7 am and drank quite heavily after a meal at 9pm. I was fine minus a little flushed face and nerves in the beginning. I skipped that nights pill and resumed. Now on day 6, I'm having more drinks! But took my evening pill. We'll see! Its a little sad I couldn't abstain, but it is what it is! Bottoms up lushes!
I debated on day 3 whether or not to drink and decoded F it. I'm giving it a go. I took last pill at 7 am and drank quite heavily after a meal at 9pm. I was fine minus a little flushed face and nerves in the beginning. I skipped that nights pill and resumed. Now on day 6, I'm having more drinks! But took my evening pill. We'll see! Its a little sad I couldn't abstain, but it is what it is! Bottoms up lushes!
Hope I haven't affected the meds working...especially cus I didn't think ahead and remind myself not to drink while on these! Dont wana take them again!
It was after I was done my glass of wine before I suddenly realized, "Wait a minute.. I feel like I remember once hearing that drinking while on Flagyl will make me sick.." I Googled to verify.. Yep. -- I FREAKED. People, I quite literally swallowed my pills down with the wine. There was no time around it, no few hour buffer on either side of the dose.. No, I drank the pills down with the fucking wine.
I then started to Google how I could make myself throw up, thinking that maybe if the pill hadn't completely dissolved yet, there would be less of a chance that I would become violently ill. I read that if you chug salt water, it will make you vomit immediately. I drank a whole cup of warm salt water, and nothing. I tried sticking my fingers down my throat, but barely anything came up because my body was trying to fight the gag reflex, and what did come up was so vile. So I drank two or three more cups of water to dilute the salt and put increased pressure on my stomach, hopefully triggering me to vomit. No. Now I was full, salty, and still freaking out.
I had been up way too long, and needed to try to get some sleep before going into my third shift. I finally accepted that I was going to throw up one way or the other, grabbed a trashcan with a double liner, put it next to bed, and found this page. I read, read, read, read these posts.. Praying I would be one of the lucky ones.. And trying to not let me psych myself out. I would start to think about vomiting, start to feel sick, talk myself down, tell myself it's only mental, and then I would feel ok again. I have anxiety issues anyway, so they were obviously in full gear.
Long story short, aside from just feeling really groggy (which may have had something to do with not being able to sleep because I was freaking out, and being really tired to begin with), I was fine. I got up to pee about five times, but I never felt nauseous, I never puked.
My body is usually pretty sensitive to things, so I'm surprised it didn't affect me. I had been on 500mg twice a day for three or four days at this point.
first i must say that last week went through a gastrophscopy and a colonoscopy both at same time. i was given metro clarithroycin and omeprazole to take for a week. already suffering from said procedures and an upper hernia thought sod it today. 3 days in after starting the course. i needed a drink felt miserable due to anxiety and bad dreams metro was causing so ended up having 4 pints of 4.7% cider and 2 double baileys. i'm fine no effects at all. i also take every day regular meds so surprised with no side effects
Started at 6pm. It is now 7:22 and I've had 2. No ill effects as of now. I will report back later.
Les
Took with icecream . Now I'm nervous because I didn't know not to way stuff with propylene glycol.
Help will I get sick during the night
I did get a bit, a lot more buzz than usual.
I did not drink at all over the course. I stopped drinking 2 days before taking.
On my 3rd day after lunch (no alcohol) I all of a sudden felt like puking, but didn't; I had chicken and gravy... is there alcohol in gravy?
I finally waiting 60hrs before drinking and am on my 2nd glass of beer as I type. I drank one glass in 30mins, now working on 2nd.
So far so good.
To all my people: I am on the 0.75% vaginal gel (administered at night). I waited until Day 3 to test the waters. I drank about a 1/4 glass of red wine maybe 2 hours before my nightly dose. I didn't have any reaction when I initially drank the wine, and I didn't feel any differently when I took the dose. I did have some really weird dreams, but that could just be the med itself. Today, approximately 17 hours after my previous dose, I had a whole glass of sangria. That was about an hour ago and I have experienced no reaction whatsoever, not even the "extra drunk" feeling. I'm going with it and having a glass of red wine, slowly.
I think it might be okay to drink while taking the vaginal gel. I am mainly seeing adverse reactions from people taking the tablets, so hopefully guinea-pigging the gel is doing someone a favor. I'm trying to make sure drinking on New Year's Eve is gonna be okay, and so far so good. I'll report back if things go awry.
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How long does alcohol stay in your system?
Matt, thank you for this forum, I do wonder if the comments on here might actually be useful to the nanny state pharmaceutical industry!
I’ll report back in a day or two on how this goes! I’m due for about 30 IPAs after this $#!T Show! Cheers!
I couldn't walk on my own & was afraid to sleep in case I didn't wake up. Woke up this morning and felt like crap. I'm exhausted, achy, nauseous, and weak still as if my body has been put thru the wringer.
DON'T RISK DRINKING ON ANY FORM OF THIS MED. Some people said they were fine after a few drinks and good for them but its not worth the risk. This was a huge regret. I could have died if alone. Who knows.
Read more at How long does alcohol stay in your system
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I seriously want to kick myself in the face for not listening... So like all the rest of y’all, my dumbass was curious to know and hoping I was the 5% of the people that can drink on this and have no side effects... HA!! I hate myself right now.
So I’ve been on this shit for 4 days now, last night before I even had a sip of alcohol I started googling like crazy on mixing alcohol and metro. Everything I read was awful. You would think my dumbass would have taken all that info into consideration, but nah, I was like fuck it, I drink all the time my livers got this.. So at midnight I literally had half a vodka and cranberry. I waited an hour, nothing. So I was like fuck yea I’m in it to win it. So I drank the other half of my drink and no lie not even 10 mins later, it hit me like a ton of bricks... Here it is 8:20am and I’m vomiting actually I’m dry heefing bc I have nothing left to throw up.... So yea guys don’t be an idiot like me. I’ve even taken nausea medicine and that shit didn’t work. And for the 5% of y’all lucky fuckers, I hate y’all! FML!!
Over and out!! 😉
Claire x
Good luck to all and Merry Christmas!
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Woke up in morning with headache and its 1 PM, still feel little queasy aftre another dose of flagyl.
Recomendation : Dont Drink ! If you really wnat to dont push you limit, first know your limit. But once you reach your limit, it will be really bad experience, be ready for it!